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Plug-in required click here for more information complete record title acquired selective iga deficiency induced by dietary bovine iga name klartag, ayelet (author); ron, yacov (chair); denhardt, david (internal member); chen, chiann-chyi (outside member); rutgers university (degree grantor); graduate school - new brunswick (school); degree date 2007 date created 2007 subject cell and developmental biology, immunoglobulin a description selective iga deficiency (sigad) is the most common immunodeficiency in humans. average retail price viagra Auto-reactive antibodies to human iga are found in the serum of 20-40% of individuals with sigad.
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It is unknown whether these antibodies play a role in the pathogenesis of this immunodeficiency, and most researchers believe that they are secondary to the onset of sigad. viagra results men However, it is possible that in these individuals, the anti-iga antibodies are in fact responsible for the removal of iga from serum, and are originally generated against xenogeneic iga. can you buy viagra over counter usa To examine this hypothesis, the presence of anti-bovine and anti-human iga antibodies was tested by elisa in serum samples from iga-deficient and control individuals. do you need prescription to buy viagra in canada All 14 of the iga-deficient individuals that were tested had igg anti-bovine iga antibodies (100%), whereas only 8 had igg anti-human iga antibodies (57%).
Individuals with both anti-bovine and anti-human iga antibodies always had a higher titre against bovine iga than against human iga.
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Of 18 control individuals who have normal serum levels of iga and no anti-human iga antibodies, a surprisingly high proportion (61%) had igg anti-bovine iga antibodies in their serum.
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These results strongly support the hypothesis that the anti-human iga antibodies found in iga-deficient individuals are originally produced against xenogeneic iga, specifically bovine iga found in dietary beef products.
These antibodies can be found in many norma.
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